Overview

Quick reference

Summary

Symptomatic carotid stenosis is the state of carotid disease in which atherosclerotic narrowing of the internal carotid artery has caused an ipsilateral transient ischaemic attack (TIA), ischaemic stroke or retinal event. The risk of recurrent stroke is highest in the first days after the event, so assessment and treatment are urgent. Duplex ultrasound is the first test, and plaque imaging and the Carotid Artery Risk (CAR) score help to identify patients at lower risk on medical therapy alone. Every patient receives best medical therapy. Carotid endarterectomy (CEA) is added for severe stenosis and considered for moderate stenosis, and it is preferred to carotid artery stenting (CAS) soon after symptoms and in older patients. After revascularisation, patients are followed with duplex ultrasound for restenosis.

Takeaways

  1. 1

    Revascularise eligible patients as soon as they are neurologically stable, because recurrence clusters in the first days.

  2. 2

    Prefer endarterectomy to stenting soon after symptoms and in older patients, because stenting then carries the higher procedural risk.

  3. 3

    Recognise near-occlusion, carotid webs, free-floating thrombus and chronic occlusion, and decide on each separately from ordinary stenosis.

Start here

  1. Editor's Choice - Risk of Stroke before Revascularisation in Patients with Symptomatic Carotid Stenosis: A Pooled Analysis of Randomised Controlled TrialsFisch 2021 · Eur J Vasc Endovasc Surg
  2. Duplex ultrasound for diagnosing symptomatic carotid stenosis in the extracranial segmentsCassola 2022 · Cochrane Database Syst Rev
  3. Editor's Choice - European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery DiseaseNaylor 2023 · Eur J Vasc Endovasc Surg
  4. Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trialBonati 2018 · Lancet Neurol
  5. Carotid near-occlusion diagnostics and its consequences: A systematic reviewJohansson 2025 · Eur Stroke J
  6. Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosisRothwell 2003 · Lancet · landmark
  7. Long-term outcomes of stenting and endarterectomy for symptomatic carotid stenosis: a preplanned pooled analysis of individual patient dataBrott 2019 · Lancet Neurol · pivotal
Next · Chapter 3 of 3Carotid stenting and TCARTransfemoral, transradial and transcarotid stenting of carotid stenosis, from device and route choice to in-stent restenosis.

Symptomatic carotid stenosis

Healthcare professionals · Updated 1 Nov 2026 · G. Kalarakis

Carotid diseaseChapter 2 of 3
Quick reference

Summary

Symptomatic carotid stenosis is the state of carotid disease in which atherosclerotic narrowing of the internal carotid artery has caused an ipsilateral transient ischaemic attack (TIA), ischaemic stroke or retinal event. The risk of recurrent stroke is highest in the first days after the event, so assessment and treatment are urgent. Duplex ultrasound is the first test, and plaque imaging and the Carotid Artery Risk (CAR) score help to identify patients at lower risk on medical therapy alone. Every patient receives best medical therapy. Carotid endarterectomy (CEA) is added for severe stenosis and considered for moderate stenosis, and it is preferred to carotid artery stenting (CAS) soon after symptoms and in older patients. After revascularisation, patients are followed with duplex ultrasound for restenosis.

Takeaways

  1. 1

    Revascularise eligible patients as soon as they are neurologically stable, because recurrence clusters in the first days.

  2. 2

    Prefer endarterectomy to stenting soon after symptoms and in older patients, because stenting then carries the higher procedural risk.

  3. 3

    Recognise near-occlusion, carotid webs, free-floating thrombus and chronic occlusion, and decide on each separately from ordinary stenosis.

Start here

  1. Editor's Choice - Risk of Stroke before Revascularisation in Patients with Symptomatic Carotid Stenosis: A Pooled Analysis of Randomised Controlled TrialsFisch 2021 · Eur J Vasc Endovasc Surg
  2. Duplex ultrasound for diagnosing symptomatic carotid stenosis in the extracranial segmentsCassola 2022 · Cochrane Database Syst Rev
  3. Editor's Choice - European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery DiseaseNaylor 2023 · Eur J Vasc Endovasc Surg
  4. Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trialBonati 2018 · Lancet Neurol
  5. Carotid near-occlusion diagnostics and its consequences: A systematic reviewJohansson 2025 · Eur Stroke J
  6. Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosisRothwell 2003 · Lancet · landmark
  7. Long-term outcomes of stenting and endarterectomy for symptomatic carotid stenosis: a preplanned pooled analysis of individual patient dataBrott 2019 · Lancet Neurol · pivotal

Next · Chapter 3 of 3Carotid stenting and TCARTransfemoral, transradial and transcarotid stenting of carotid stenosis, from device and route choice to in-stent restenosis.