Overview
Summary
Within carotid disease, asymptomatic carotid stenosis is atherosclerotic narrowing of the internal carotid artery found before it has caused an ipsilateral stroke, transient ischaemic attack (TIA) or retinal event, often incidentally on duplex ultrasound. Its stroke risk on modern medical therapy is low and has fallen since the first surgical trials. The risk rises with the degree of stenosis and with markers of a vulnerable plaque, such as intraplaque haemorrhage, silent infarction on brain imaging, progression of the stenosis and microembolic signals on transcranial Doppler. Every patient receives intensive medical therapy, and the decision is whether carotid endarterectomy (CEA) or carotid artery stenting (CAS) adds enough to it, in a given patient, to justify its early procedural risk. Patients are followed for ipsilateral symptoms, progression of untreated stenosis and restenosis after a procedure.
Takeaways
- 1
Add revascularisation to medical therapy only for patients with higher-risk features, long life expectancy and low procedural risk.
- 2
Estimate stroke risk from plaque features, silent infarction and microembolic signals, not from the degree of stenosis alone.
- 3
Do not offer revascularisation to improve cognition, because neither stenting nor endarterectomy improved it in randomised trials.
Start here
- Stroke risk management in carotid atherosclerotic disease: a clinical consensus statement of the ESC Council on Stroke and the ESC Working Group on Aorta and Peripheral Vascular DiseasesMusialek 2025 · Cardiovasc Res
- Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implicationsSaba 2019 · Lancet Neurol
- Editor's Choice - European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery DiseaseNaylor 2023 · Eur J Vasc Endovasc Surg
- Temporal trends in short- and long-term outcomes after carotid interventions for symptomatic or asymptomatic stenosis: a systematic review and meta-analysisde Bresser 2026 · Eur Stroke J
- 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trialHalliday 2010 · Lancet · landmark
- Medical management and revascularization for asymptomatic carotid stenosisBrott 2026 · N Engl J Med · pivotal
Summary
Within carotid disease, asymptomatic carotid stenosis is atherosclerotic narrowing of the internal carotid artery found before it has caused an ipsilateral stroke, transient ischaemic attack (TIA) or retinal event, often incidentally on duplex ultrasound. Its stroke risk on modern medical therapy is low and has fallen since the first surgical trials. The risk rises with the degree of stenosis and with markers of a vulnerable plaque, such as intraplaque haemorrhage, silent infarction on brain imaging, progression of the stenosis and microembolic signals on transcranial Doppler. Every patient receives intensive medical therapy, and the decision is whether carotid endarterectomy (CEA) or carotid artery stenting (CAS) adds enough to it, in a given patient, to justify its early procedural risk. Patients are followed for ipsilateral symptoms, progression of untreated stenosis and restenosis after a procedure.
Takeaways
- 1
Add revascularisation to medical therapy only for patients with higher-risk features, long life expectancy and low procedural risk.
- 2
Estimate stroke risk from plaque features, silent infarction and microembolic signals, not from the degree of stenosis alone.
- 3
Do not offer revascularisation to improve cognition, because neither stenting nor endarterectomy improved it in randomised trials.
Start here
- Stroke risk management in carotid atherosclerotic disease: a clinical consensus statement of the ESC Council on Stroke and the ESC Working Group on Aorta and Peripheral Vascular DiseasesMusialek 2025 · Cardiovasc Res
- Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implicationsSaba 2019 · Lancet Neurol
- Editor's Choice - European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery DiseaseNaylor 2023 · Eur J Vasc Endovasc Surg
- Temporal trends in short- and long-term outcomes after carotid interventions for symptomatic or asymptomatic stenosis: a systematic review and meta-analysisde Bresser 2026 · Eur Stroke J
- 10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trialHalliday 2010 · Lancet · landmark
- Medical management and revascularization for asymptomatic carotid stenosisBrott 2026 · N Engl J Med · pivotal