Overview

Quick reference

Summary

An unruptured brain arteriovenous malformation (AVM) is one found before it has bled, after a seizure or headache or on imaging done for another reason. The clinical question is whether a low but lifelong risk of haemorrhage justifies the up-front risk of treatment. The decision to treat or observe is weighed against the ARUBA randomised trial, which favoured medical management alone, and against the consensus of the European neurosurgical, neurointerventional and radiosurgical societies (EANS, ESMINT, EGKS), which frames the decision by Spetzler-Martin grade. When treatment is chosen, the size, location and grade of the lesion guide the choice between microsurgery, stereotactic radiosurgery (SRS) and embolisation. Microsurgery removes the AVM at once, whereas SRS obliterates the nidus only after a latency of years, so imaging follow-up after SRS is long.

Takeaways

  1. 1

    Consider treatment for Spetzler-Martin grade I–II AVMs, and decide higher grades case by case in an experienced interdisciplinary team.

  2. 2

    Counsel from the risk of a first haemorrhage over the remaining lifetime, adjusted for age, associated aneurysm and deep location.

  3. 3

    Follow with MRI after radiosurgery, and call the AVM cured only when catheter angiography confirms obliteration.

Start here

  1. Risk of Future Hemorrhage From Unruptured Brain Arteriovenous Malformations: The Multicenter Arteriovenous Malformation Research Study (MARS)Kim 2025 · JAMA Neurol
  2. European consensus conference on unruptured brain AVMs treatment (Supported by EANS, ESMINT, EGKS, and SINCH)Cenzato 2017 · Acta Neurochir (Wien)
  3. Management of Adult Unruptured Brain Arteriovenous Malformations: An Updated Network Meta-AnalysisDmytriw 2023 · Neurointervention
  4. Stereotactic Radiosurgery for Spetzler-Martin Grade I and II Arteriovenous Malformations: International Society of Stereotactic Radiosurgery (ISRS) Practice GuidelineGraffeo 2020 · Neurosurgery
  5. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trialMohr 2014 · Lancet · landmark
  6. Medical management with interventional therapy versus medical management alone for unruptured brain arteriovenous malformations (ARUBA): final follow-up of a multicentre, non-blinded, randomised controlled trialMohr 2020 · Lancet Neurol · pivotal
Next · Chapter 2 of 3Ruptured brain AVMIntracerebral haemorrhage from a brain AVM: finding the cause, timing and choice of treatment, prognosis and seizures.

Unruptured brain AVM

Healthcare professionals · Updated 10 Nov 2026 · G. Kalarakis

Brain arteriovenous malformationsChapter 1 of 3
Quick reference

Summary

An unruptured brain arteriovenous malformation (AVM) is one found before it has bled, after a seizure or headache or on imaging done for another reason. The clinical question is whether a low but lifelong risk of haemorrhage justifies the up-front risk of treatment. The decision to treat or observe is weighed against the ARUBA randomised trial, which favoured medical management alone, and against the consensus of the European neurosurgical, neurointerventional and radiosurgical societies (EANS, ESMINT, EGKS), which frames the decision by Spetzler-Martin grade. When treatment is chosen, the size, location and grade of the lesion guide the choice between microsurgery, stereotactic radiosurgery (SRS) and embolisation. Microsurgery removes the AVM at once, whereas SRS obliterates the nidus only after a latency of years, so imaging follow-up after SRS is long.

Takeaways

  1. 1

    Consider treatment for Spetzler-Martin grade I–II AVMs, and decide higher grades case by case in an experienced interdisciplinary team.

  2. 2

    Counsel from the risk of a first haemorrhage over the remaining lifetime, adjusted for age, associated aneurysm and deep location.

  3. 3

    Follow with MRI after radiosurgery, and call the AVM cured only when catheter angiography confirms obliteration.

Start here

  1. Risk of Future Hemorrhage From Unruptured Brain Arteriovenous Malformations: The Multicenter Arteriovenous Malformation Research Study (MARS)Kim 2025 · JAMA Neurol
  2. European consensus conference on unruptured brain AVMs treatment (Supported by EANS, ESMINT, EGKS, and SINCH)Cenzato 2017 · Acta Neurochir (Wien)
  3. Management of Adult Unruptured Brain Arteriovenous Malformations: An Updated Network Meta-AnalysisDmytriw 2023 · Neurointervention
  4. Stereotactic Radiosurgery for Spetzler-Martin Grade I and II Arteriovenous Malformations: International Society of Stereotactic Radiosurgery (ISRS) Practice GuidelineGraffeo 2020 · Neurosurgery
  5. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trialMohr 2014 · Lancet · landmark
  6. Medical management with interventional therapy versus medical management alone for unruptured brain arteriovenous malformations (ARUBA): final follow-up of a multicentre, non-blinded, randomised controlled trialMohr 2020 · Lancet Neurol · pivotal

Next · Chapter 2 of 3Ruptured brain AVMIntracerebral haemorrhage from a brain AVM: finding the cause, timing and choice of treatment, prognosis and seizures.