Overview
Summary
A brain arteriovenous malformation (AVM) is a tangle of abnormal vessels, the nidus, through which arteries drain directly into veins without a capillary bed. Most AVMs are sporadic, and multiple lesions suggest hereditary haemorrhagic telangiectasia (HHT). An AVM comes to attention through intracerebral haemorrhage or seizures, or as an incidental finding on imaging. Imaging defines its angioarchitecture, and the grade of the lesion frames the choice between observation, microsurgery, stereotactic radiosurgery (SRS) and embolisation, made by a multidisciplinary neurovascular team. The decisions that follow depend on whether the AVM has bled. The unruptured brain AVM page covers whether to treat an AVM that has not bled and how to follow it after radiosurgery. The ruptured brain AVM page covers the search for an AVM behind a haemorrhage, the timing of treatment and recovery.
Takeaways
- 1
Grade every AVM with the Spetzler-Martin and supplementary scales before weighing observation, microsurgery, radiosurgery or embolisation.
- 2
Report angioarchitecture in Joint Writing Group terms, so that grading and risk features are comparable between readers.
- 3
Follow children with angiography for years after apparent cure, because the nidus can recur.
Start here
- Brain arteriovenous malformationsLawton 2015 · Nat Rev Dis Primers
- Reporting of angiographic studies in patients diagnosed with a cerebral arteriovenous malformation: a systematic reviewDas 2024 · F1000Res
- Management of Brain Arteriovenous Malformations: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke AssociationDerdeyn 2017 · Stroke
- Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic TelangiectasiaFaughnan 2020 · Ann Intern Med
- Somatic Activating KRAS Mutations in Arteriovenous Malformations of the BrainNikolaev 2018 · N Engl J Med · landmark
- A proposed grading system for arteriovenous malformationsSpetzler 1986 · J Neurosurg · landmark
Summary
A brain arteriovenous malformation (AVM) is a tangle of abnormal vessels, the nidus, through which arteries drain directly into veins without a capillary bed. Most AVMs are sporadic, and multiple lesions suggest hereditary haemorrhagic telangiectasia (HHT). An AVM comes to attention through intracerebral haemorrhage or seizures, or as an incidental finding on imaging. Imaging defines its angioarchitecture, and the grade of the lesion frames the choice between observation, microsurgery, stereotactic radiosurgery (SRS) and embolisation, made by a multidisciplinary neurovascular team. The decisions that follow depend on whether the AVM has bled. The unruptured brain AVM page covers whether to treat an AVM that has not bled and how to follow it after radiosurgery. The ruptured brain AVM page covers the search for an AVM behind a haemorrhage, the timing of treatment and recovery.
Takeaways
- 1
Grade every AVM with the Spetzler-Martin and supplementary scales before weighing observation, microsurgery, radiosurgery or embolisation.
- 2
Report angioarchitecture in Joint Writing Group terms, so that grading and risk features are comparable between readers.
- 3
Follow children with angiography for years after apparent cure, because the nidus can recur.
Start here
- Brain arteriovenous malformationsLawton 2015 · Nat Rev Dis Primers
- Reporting of angiographic studies in patients diagnosed with a cerebral arteriovenous malformation: a systematic reviewDas 2024 · F1000Res
- Management of Brain Arteriovenous Malformations: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke AssociationDerdeyn 2017 · Stroke
- Second International Guidelines for the Diagnosis and Management of Hereditary Hemorrhagic TelangiectasiaFaughnan 2020 · Ann Intern Med
- Somatic Activating KRAS Mutations in Arteriovenous Malformations of the BrainNikolaev 2018 · N Engl J Med · landmark
- A proposed grading system for arteriovenous malformationsSpetzler 1986 · J Neurosurg · landmark